E3257
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E3257
Sigma-Aldrich
Ethylene glycol-bis(succinic acid N-hydroxysuccinimide ester)
powder
| Synonym: | Di(N-succinimidyl) ethylene glycol disuccinate, EGS, Ethylene glycol bis(succinimidyl succinate), Ethylene glycol disuccinate di(N-succinimidyl) ester |
| CAS Number: | 70539-42-3 |
| Linear Formula: | C18H20N2O12 |
| Molecular Weight: | 456.36 |
| Beilstein Registry Number: | 9167119 |
| MDL number: | MFCD00049057 |
| PubChem Substance ID: | 24894501 |
Description
| Application | A homobifunctional, cleavable cross-linking reagent. Typically, coupled to molecules containing primary amines by amide bonds buffered at pH 7.5 (6.5-8.5). The linkage provides a 12-atom spacer. |
| Features and Benefits | The ethylene glycol linkage is cleavable by hydroxylamine. |
Properties
| form | powder |
| solubility | acetic acid: water (1:1): ≤50 mg/mL |
| DMF: soluble | |
| storage temp. | 2-8°C |
Safety
| Personal Protective Equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
| WGK Germany | 3 |
References
| reference | Massague, J., et al., Affinity labeling of multiplication stimulating activity receptors in membranes from rat and human tissues. J. Biol. Chem. 256, 2122-2125, (1981) Abstract |
| Abdella, P.M., et al., A new cleavable reagent for cross-linking and reversible immobilization of proteins. Biochem. Biophys. Res. Commun. 87, 734-742, (1979) Abstract |
